Effects of Chronic Hypercapnia on Blood Volume, Plasma Volume and Red Cell Volume in Relation to the Submarine Environment
Abstract
Blood volume in guinea pigs, estimated on the basis of simultaneous measurement of red cell volume using chromium-51 tagged red cells and plasma volume with iodinated human albumin (I-125), was found to be more accurate than blood volume data calculated from separate determinations of red cell volume (chromium-51) and plasma volume (I-131). In chronic hypercapnia total blood and cell volume was found to increase during the uncompensated phase and increase to a greater extent during the compensated phase, while the plasma volume did not change significantly. The first rise was attributed to the release of blood stores from the spleen and liver while the later rise was attributed to an increased rate of erythropoiesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 24, 1969
- Accession Number
- AD0715628
Entities
People
- George T. Baker Iii
- Karl E. Schaefer
Organizations
- Naval Submarine Medical Research Laboratory