Preparation of a Coral Snake Antivenin From Goat Serum.
Abstract
A monovalent antivenin was prepared by immunizing goats with detoxified coral snake venom obtained by photooxidation with visible light in the presence of methylene blue. Goats inoculated with this attenuated venom produced an immunoglobulin which protected mice against many-fold doses of the unaltered venom. Neither local nor systemic effects were observed in goats or mice. The effective and harmless toxoid obtained could be used for active immunization, in suitable circumstances, as well as for the production of antisera for passive immunization or treatment of coral snakebites. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 29, 1970
- Accession Number
- AD0715699
Entities
People
- Edith Bowles-ledford
- Joyce G. Daly
- Thomas A. Billings
- Walter F. Kocholaty
Organizations
- United States Army Medical Research Laboratory