The Role of the Central Nervous System Cholinergic Mechanisms in Behavior and Learning

Abstract

The principal purpose of this study was to investigate the possible differential effects of LSD as a function of procedural variations in performance of delayed response tasks. In general, LSD was found to impair delayed response performance in the monkey. From the standpoint of dose-effect relationships, the results suggest a positive correlation between magnitude of dose and extent of functional impairment. A tendency toward rapidly developing tolerance was observed. A 'placebo effect' in response to the control agent (sterile water) was encountered in a significant number of monkeys.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1966
Accession Number
AD0718136

Entities

People

  • Pericles Spyropoulos
  • Perry Black

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Central Nervous System
  • Drug Abuse
  • Experimental Design
  • Health Services
  • Laboratory Animals
  • Lysergic Acids
  • Maryland
  • Nervous System
  • Scientific Research
  • Training
  • United States
  • United States Government

Fields of Study

  • Psychology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design