Effects of Lysergic Acid and Its Derivatives on Rhinencephalic Electrograms
Abstract
Six macaca mulatta monkeys had chronically implanted electrodes over the frontal and occipital cortex, and in the septal, caudate, and hippocampal regions. Thirty-two studies were done on lysergic acid derivatives as d-LSD-25, ALD-52, MLD-41, LSM, DAM, LPD, 1-LSD-25, BOL and UML to determine possible correlations between the psychotogenic effect of these drugs and the effect on the subcortical electrogram. No correlation was found between the pyretogenic, antiserotonin or psychotogenic effect as found by Isbell studying these same drugs on humans. However, there did appear to be a good correlation between the behavioral effect on monkeys and rhinencephalic paroxysmal hypersynchronous activity, particularly in the septal region. Five studies with mescaline also revealed a similar correlation. It would seem that even taking into account species differences, rhinencephalic paroxysmal hypersynchronous abnormality is a good indication of psychotogenic effects of a drug.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 26, 1959
- Accession Number
- AD0720279
Entities
People
- Russell R. Monroe
Organizations
- Tulane University of Louisiana