The Effect of d-LSD-25 and Related Compounds on the Subcortical Electrograms

Abstract

One phase of the project was to test the effect of d-LSD-25 and related compounds on the subcortical electrograms to see whether there could be demonstrated correlations between paroxysmal hypersynchronous activity in the septal and/or hippocampal region and known psychotomimetic effect. A second phase of this study was to test the effect of serotonin on the animal by giving a monoamineoxidase inhibitor (phenylisopropylhydrosine) combined with a serotonin precursor 5-hydroxytryptophane which crosses the blood brain barrier. Three studies were also done giving animals EA-1476 in doses ranging from 125 to 500 gamma per kilo.

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Document Details

Document Type
Technical Report
Publication Date
Jan 20, 1959
Accession Number
AD0720281

Entities

People

  • Russell R. Monroe

Organizations

  • Tulane University of Louisiana

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amplitude
  • Anatomy
  • Biological Sciences
  • Blood
  • Blood-Brain Barrier
  • Brain
  • Buildings And Structures
  • Chemical Warfare
  • Chemical Warfare Laboratories
  • Classification
  • Contractors
  • Contracts
  • Hippocampus
  • Inhibitors
  • Mental Health
  • Precursors
  • Serotonin

Readers

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  • Neuroscience