Research in Intravascular Coagulation at Karolinska Institute, Stockholm, Sweden,

Abstract

One of the primary research interests in the Thoracic Clinic of the Karolinska Institute is the hemodynamic changes occurring in the state of DIC. In investigating the mechanisms by which intravascular clotting affects vascular tone and tissue perfusion, it was found that platelets released vasoactive adenine nucleotides during thrombin infusion into defibrinogenated dogs. These nucleotides then caused vasodilatation and decreased vascular resistance. Defibrinogenation has also been shown to prevent clotting after surgical manipulation of veins or insertion of prosthetic venous grafts. (Author)

Document Details

Document Type
Technical Report
Publication Date
Dec 04, 1970
Accession Number
AD0720304

Entities

People

  • Clifford M. Herman

Organizations

  • Office of Naval Research

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomolecules
  • Blood Coagulation Factors
  • Carbohydrates
  • Chemical Compounds
  • Diffusion
  • Food
  • Infusions
  • Nucleotides
  • Perfusion
  • Resistance

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • European Security and Defence Policy (ESDP).
  • Trauma Surgery or Emergency Medicine.