Effects of Monoamine Oxidase Inhibitors and Reserpine on Brain Amines in Altitude-Exposed Rats.
Abstract
Groups of rats were injected with either pargyline, Parnate, Catron, or reserpine (75 mg./kg., 5 mg./kg., 5 mg./kg., and 5 mg./kg. respectively) and taken to a simulated altitude of 18,500 ft. The expected rise in the brain monoamine (norepinephrine and serotonin) levels after administration of monoamine oxidase inhibitors and the decrease of norepinephrine by reserpine were attenuated by altitude exposure. In another experiment, 100 percent oxygen was substituted for ambient air. In this case, the attenuation of monoamine elevations by the inhibitors was reversed. However, the added oxygen did not reverse the attenuation of the norepinephrine decrease by reserpine. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1971
- Accession Number
- AD0720808
Entities
People
- James H. Merritt
- Miguel A. Medina
Organizations
- United States Air Force School of Aerospace Medicine