Brain and Heart Accumulation of Bromotrifluoromethane
Abstract
One hundred seventy-six albino rats were divided into 11 groups of 16 rats each. The rats were exposed by groups to 70-75% CBrF3 in 02 for 5 minutes. The rats were serially killed throughout the exposure and 55-minute postexposure period. The brains and hearts from the rats in 10 of the 11 groups were rapidly excised and placed in vials of heptane. The contents of the vials were subsequently analyzed for CBrF3. Blood samples were obtained from the rats in the 11th group which was treated identically to the other 10 groups. After the first minute of the 5-minute exposure, the concentration of CBrF3 in the brains rose approximately twice as rapidly as the concentration in the hearts. At the end of the 5-minute exposure the brain concentration was approximately 50% greater than the heart concentration. The heart concentration did not differ significantly from the blood concentration. The postexposure rates of decline of the tissue concentrations of CBrF3 were approximately equal. The brain required almost exactly 1 minute longer to reach a given concentration than the heart. Only trace amounts of CBrF3 were detectable beyond 10 minutes postexposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1971
- Accession Number
- AD0721211
Entities
People
- Ethard W. Van Stee
- Kenneth C. Back
Organizations
- Air Force Research Laboratory