Maximum Permissible Limits of Contaminants for Divers' Breathing Gas: An Overview
Abstract
Navy biomedical research strives to establish limits of contamination of breathing gas tolerable to Naval personnel in operational settings. Customary steps in the determination of these limits include exposure of laboratory animals to the contaminant followed by observation of patterns of morbidity and mortality in these animals. This data is then extrapolated to humans under exposure conditions that may or may not be similar to those of the laboratory experiment. In addition to animal-human and time frame extrapolations, establishment of limits applicable to the hyperbaric environments must also consider the relevance of partial pressure increase and the possible synergism or antagonism among multiple contaminants. This paper elaborates on these steps in the chain of biomedical investigation of contaminant toxicity and the pertinent pitfalls associated with them.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 12, 1970
- Accession Number
- AD0721681
Entities
People
- Joseph D. Bloom
Organizations
- Naval Submarine Medical Research Laboratory