Effects of Injected Histamine on Intracranial Pressure and Systemic Blood Pressure.
Abstract
To measure intracranial and systemic arterial pressures, ten Macaca mulatta monkeys were surgically prepared with catheters in the subdural space and in the abdominal aorta (via the femoral artery). The monkeys were stabilized in a state of light surgical anesthesia, then administered 50 micrograms/kg. of histamine intravenously over a 30-second injection period. ICP and blood pressure were monitored for 30 minutes. ICP reached a maximum pressure of 165% of baseline value at 2 minutes post-injection and was down to 110% of baseline at the end of the 30-minute observation period. Blood pressure reached the nadir of 72% of baseline at 4 minutes postinjection, and at the end of 30 minutes the pressure had returned to 102% of baseline value. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1971
- Accession Number
- AD0726543
Entities
People
- Hughes P. Rue
- John W. Watters
- Samuel J. Mcchesney
Organizations
- United States Air Force School of Aerospace Medicine