Expansion of the Fragiligraph Scale by Computerization and Its use in Toxicological Investigation,
Abstract
Changes in the osmotic fragility characteristics of red blood cells have been used to diagnose and differentiate various hemolytic disorders for a number of years. More recently, osmotic fragility has been used to evaluate the toxic or hemolytic actions of drugs and chemicals as well as exotic space-cabin atmospheres. The use of this technique was stimulated by the invention of the fragiligraph. As presently conceived, the fragiligraphy rapidly records, in a continuous fashion, the spectrum of osmotic fragilities of red blood cells in a small quantity of blood. Computer techniques which are applied to standard fragiligraph recordings for the linearization and first level analysis of data obtained from toxicologic studies are reported.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1970
- Accession Number
- AD0727513
Entities
People
- Don Card
- George Ishiguro
- Henry A. Leon
- Marjorie Fuji
- Maureen Mctigue
Organizations
- Air Force Research Laboratory