Effects of Inhalation of Freon 113 on Laboratory Animals,
Abstract
Four monkeys, 8 dogs, 40 mice and 50 rats were exposed continuously to 2000 ppm Freon 113 in a Thomas Dome for 14 days. This exposure produced no mortalities nor adverse symptomatology. There were no significant alterations in hematological values, clinical chemistries, electroencephalographic findings, body weights, or organ to body weight ratios. The effect of 2% Freon 113 on nicotinic transmission through the stellate ganglion of the spinal dog was also evaluated. This exposure induced a reduction in nicotinic transmission comparable to 2% halothane. The effects of this compound on muscarinic ganglionic transmission were not evaluated. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1970
- Accession Number
- AD0727524
Entities
People
- James D. Macewen
- Kenneth C. Back
- Paul M. Chikos
- Vernon L. Carter
Organizations
- Air Force Research Laboratory