Manufacture of Six Lots of Staphylococcus Enterotoxoid B

Abstract

This contract was a best effort attempt to prepare six lots of Staphylococcus Enterotoxoid B in such a manner as to be suitable for human clinical trial. The facilities, manufacturing process and test procedures were designed for submission to the Division of Biologic Standards of the National Institutes of Health as an Investigational New Drug. The United States Army Medical Research and Development Command supplied purified Staphylococcus Enterotoxin B. They further supplied an outline of a formaldehyde detoxification process and procedures for monkey toxicity and safety tests. Other routine tests normally required by the Division of Biologic Standards for various vaccine preparations were conducted in accordance with standard procedures.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1971
Accession Number
AD0727654

Entities

People

  • D. S. Mabry

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Toxins
  • Biomedical Research
  • Body Weight
  • Contracts
  • Detoxification
  • Filtration
  • Formaldehyde
  • Manufacturing
  • New York
  • Packaging
  • Production
  • Production Engineering
  • Rodents
  • Standards
  • Tasers
  • United States

Readers

  • Analytical Chemistry
  • Microbial Pathology
  • Software Engineering

Technology Areas

  • Biotechnology