Radiation Inactivation of Histamine in Aqueous Solution and in Plasma

Abstract

Dilute solutions of histamine in water and plasma were given 140- to 38,000-rad doses of pulsed mixed gamma-neutron radiation. Histamine activity of the solutions was bioassayed using guinea pig ileum. Inactivation of the histamine in water was apparent at doses of 2000 rads or more. Different concentrations of histamine receiving the same dose of radiation showed an inverse relation between concentration and inactivation. Histamine in plasma showed less than 10 percent inactivation even at the highest dose used, 38,000 rads.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1971
Accession Number
AD0727982

Entities

People

  • S. L. Bradley
  • T. F. Doyle

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Aqueous Solutions
  • Biological Sciences
  • Biology
  • Health Services
  • Laboratory Animals
  • Military Research
  • Navy
  • Neutron Bombardment
  • New Mexico
  • Nuclear Energy
  • Nuclear Medicine
  • Physics Laboratories
  • Public Health
  • Radiologic Health
  • Rodents
  • Standards

Readers

  • Environmental Engineering
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology