Similar and Selective Actions of Chlorpromazine, Chlordiazepoxide and Nicotine on Shock-Produced Aggressive and Anticipatory Motor Responses in the Squirrel Monkey
Abstract
Squirrel monkeys, studied during response-independent, periodic presentation of electric shock, engaged in biting attack behavior after shock and anticipatory manual and locomotor behavior before shock. Administration of chlorpromazine, chlordiazepoxide and nicotine produced dose dependent decreases in attack reactions and simultaneous increases in anticipatory responses. At high dosages chlorpromazine and chlordiazepoxide generally suppressed while nicotine generally stimulated both response classes. Implications of these results for understanding the behavioral mode of action of antianxiety agents and advantages of the method for drug testing are noted. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1971
- Accession Number
- AD0728434
Entities
People
- G. S. Emley
- R. R. Hutchinson
Organizations
- Western Michigan University