Effects of Endotoxin on Myocardial Hemodynamics, Performance and Metabolism during Beta Adrenergic Blockade

Abstract

The question of the precise role of the heart in shock has been largely unresolved. Previous separate reports have shown that both excitatory and depressant actions on the myocardium after endotoxin are observed. The purpose of the present study was to assay the possibility of a direct myocardial toxic action of endotoxin or a circulating myocardial depressant factor released in the blood of endotoxin shocked animals. This was accomplished by utilization of beta adrenergic blockade (propranolol) under the experimental conditions of constant cardiac output and aortic pressure in an isolated canine heart preparation exchanging blood with an intact support animal shocked by endotoxin.

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Document Details

Document Type
Technical Report
Publication Date
Aug 02, 1971
Accession Number
AD0728790

Entities

People

  • C. A. Guenter
  • L. J. Greenfield
  • L. T. Archer
  • Lerner B. Hinshaw

Organizations

  • University of Oklahoma

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Flow
  • Carbon Dioxide
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Epinephrine
  • Heart
  • Heart Rate
  • Hydrostatic Pressure
  • Measurement
  • Metabolism
  • Strain Gages
  • Toxic Actions
  • Veins
  • Vena Cava

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology