High-Resolution Autoradiography of Malarial Parasites Treated with Chloroquine.

Abstract

Electron microscope autoradiography was performed on the erythrocytic stages of the rodent malarial parasite, Plasmodium berghei, after exposure to 3H-chloroquine. 3H-chloroquine becomes selectively localized within the parasite food vacuoles one hour after the drug administration, and remains in this structure up to 24 hours. This study indicated the food vacuoles as the primary site of chloroquine concentration within the parasite. (Author)

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1971
Accession Number
AD0728856

Entities

People

  • Masamichi Aikawa

Organizations

  • Case Western Reserve University

Tags

DTIC Thesaurus Topics

  • Electron Microscopes
  • Electrons
  • High Resolution
  • Microscopes
  • Optical Equipment
  • Optical Magnification Devices
  • Parasites

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Nanoscale Plasmonic Nanotechnology
  • Parasitology and Pharmacology of Malaria.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics