The Use of Intramuscular Hyoscine in the Control of Motion Sickness,
Abstract
An experiment was carried out to determine the effectiveness of intramuscularly administered hyoscine in the control of symptoms of motion sickness. Forty-two subjects who developed symptoms of nausea or vomiting when exposed to the motion of rough seas were given an intramuscular injection of either (-)-hyoscine hydrobromide (O.2 mg) or normal saline. Nineteen of the 22 subjects given hyoscine reported symptomatic improvement as opposed to nine of the twenty who received the placebo. The side effects encountered were not severe. There was an equal incidence of drowsiness in both treatment and placebo groups but the incidence of dry mouth after hyoscine was twice that in the placebo group. The dose given controlled symptoms with 15 to 30 minutes of administration and a dose of this size might be expected to afford protection for about 4 hours. An injection of this nature could therefore be of value for the rapid control of symptoms in conditions where treatment by mouth is not practicable. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1969
- Accession Number
- AD0728904
Entities
People
- J. J. Brand
- P. D. G. V. Whittingham