Morphologic Studies of Hepatitis.
Abstract
Australia antigen was shown to contain DNA polymerase, which is probably RNA dependent. The morphologic change in viral hepatitis which best explained the clinical and laboratory abnormalities is damage of the endoplasmic reticulum. Halothane hepatitis, however, was characterized by mitochondrial injury, as well as by antimitochondrial antibodies and lymphocyte mitosis stimulated by halothane. Mitochondrial variations were also related to the state of thyroid function. The immunologic features of chronic hepatitis were related to morphologic changes, namely piecemeal necrosis. The economy of collagen metabolism was elucidated in relation to hepatic fibrosis. In cholestasis, hypertrophic hypoactive endoplasmic reticulum was found to be a result of loss of enzyme activity directed towards substrates bound to the lipid portion of microsomal cytochrome P-450. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 21, 1971
- Accession Number
- AD0730347
Entities
People
- Fenton Schaffner
Organizations
- Icahn School of Medicine at Mount Sinai