Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells.
Abstract
The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract. DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The investigations on the new antimalarials WR 33063 (1600 mg x day for 6 days) and WR 30090 (690 mg x day for 3-6 days) demonstrated that these drugs were not hemolytic for G6PD deficient red cells (B- type) at the given dosages. Single dosages of Sulfalene (Kelfizin) were not hemolytic for G6PD deficient red cells transfused into normal recipients or to G6PD deficient volunteers. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1971
- Accession Number
- AD0730759
Entities
People
- E. Salvidio
- F. Ajmar
- G. Gaetani
- I. Pannacciulli
- M. Molinino