Synthesis of New Antimalerial Drugs (9-Anthracenemethanols).
Abstract
The syntheses of three O-(2-di-n-alkylamino-1-hydroxyethyl)-10- haloanthracene hydrochlorides are described. Unsuccessful attempts were made to prepare the corresponding 3,6-dibromo-10-chloro-, 3,6-dibromo-, 3-trifluoromethyl-10-chloro-, 3,10-ditrifluoromethyl, and 3,10-dichloro- analogs. It was expected that all the substituted 9-anthraldehydes would react with dimethyl sulfonium methylide to form the desired substituted 9-anthrylethylene oxide intermediates. Unfortunately this reaction was only successful where the 9-anthraldehyde contained a 10 H, Br, or Cl. Data on the 10-chloro-dibutylamine derivative show this compound to be more active than either the corresponding unsubstituted compound or the halogenated 1- or 4-phenanthrene aminoalcohols synthesized previously. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1971
- Accession Number
- AD0730795
Entities
People
- Clarence W. Huffman
- E. Patrick Lira
- James T. Traxler