Duration of Resistance to Viral Infection Following Administration of Interferon Inducers

Abstract

The duration of protection afforded by 5 known interferon inducers was determined. Groups of mice were given a single dose of statolon, maleic acid-divinyl-ether copolymer (pyran), polycytidylic/polyinosinic acid (I/C), Newcastle disease virus (NDV), or bacterial endotoxin. These groups and an untreated control group were uniformly challenged with MM virus. Survival data obtained during 20 days after infection revealed that the duration of protection varied with the inducer. The longest periods of significant protection elicited by the inducers were: endotoxin, 5 days; NDV, 8 days; I/C, 30 days; statolon or pyran, 55 days. These findings show that with the dosage used, the longest lasting protection was afforded by statolon and pyran.

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Document Details

Document Type
Technical Report
Publication Date
Aug 11, 1970
Accession Number
AD0730836

Entities

People

  • David J. Giron
  • Frank F. Pindak
  • Jerome P. Schmidt
  • Robert R. Ibarra

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Alkenes
  • Animal Diseases
  • Animals
  • Biological Factors
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Interferon
  • Maleic Acid
  • Materials
  • Proteins
  • Time Intervals
  • Wound Infections

Readers

  • Polymer Science and Engineering.
  • Virology (or Medical Virology).

Technology Areas

  • Microelectronics