Cataracts Induced in Guinea Pigs by Acetone, Cyclohexanone, and Dimethyl Sulfoxide.
Abstract
Small multiple doses of acetone, byclohexanone, and dimethyl sulfoxide, administered either topically or subcutaneously on the backs of guinea pigs over a period of 3 to 8 weeks caused cataracts in 29 out of 120 animals. Lens changes began as early as 8 weeks and as late as 6 months. They consisted of subcapsular focal or extensive vacuolated areas extending from the periphery towards the center of the lens. The histological appearance of the lenses was similar to that of senile cataracts and some forms of diabetic cataracts. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1971
- Accession Number
- AD0730902
Entities
People
- John P. Petrali
- Roy H. Rengstorff
- Van M. Sim