The Effect of Cortisol upon Lipolysis during Hypercapnia and After Beta-Adrenergic Blockade.
Abstract
Injection of 6 mg./kg. cortisol I.V. into anesthetized eucapnic dogs resulted in a significant increase in plasma free fatty acid (FFA) levels, while noninjected controls showed no significant change in FFA levels. Beta-adrenergic blocking agents propranolol and KO 592 caused a rapid return of plasma FFA's to control levels in the dogs pretreated with cortisol. Cortisol neither stimulated lipolysis during acute hypercapnia, nor synergized with the lipolytic effects of norepinephrine during acute hypercapnia. The evidence suggests that the lipolytic effect of cortisol is not mediated by inhibition of cyclic AMP breakdown. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1971
- Accession Number
- AD0731124
Entities
People
- William E. Pepelko
Organizations
- United States Air Force School of Aerospace Medicine