Effects of Anti-Inflammatory Drugs in Shock Caused by Injection of Living E. Coli Cells

Abstract

Injection of live E. coli organisms to dogs iv causes a lethal shock. Administrations of anti-inflammatory drugs (indomethacin, aminopyrine, flufenamic acid, and phenylbutazone) block partially the effects of shock on the portal vein pressure, and on the hematocrit values. The changes that follow the injection of E. coli were significantly different in the treated animals from those in the control group. Some of the other agents tested were ineffective. Thus only drugs which have an antiphlogistic effect protected against shock.

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Document Details

Document Type
Technical Report
Publication Date
Oct 30, 1971
Accession Number
AD0732492

Entities

People

  • D. D. Holmes
  • E. G. Erodes
  • J. R. Culp
  • L. B. Hinshaw

Organizations

  • University of Oklahoma

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amides
  • Anti-Inflammatory Agents
  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cell Membrane
  • Contracts
  • Endotoxins
  • Hematologic Diseases
  • Metabolism
  • Military Research
  • Oklahoma
  • United States
  • United States Government
  • Veins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology