Plasma Volume Dynamics After Hypertonic Fluid Infusions in Nephrectomized Dogs,
Abstract
Plasma volume (PV) and red cell volume (RCV) transient changes due to rapid (1 min) infusion of 12 ml/kg of 0.833 M NaHCO3 solution were measured in nephrectomized, splenectomized dogs under pentobarbital anesthesia. An 80 percent peak overshoot of PV immediately following the infusion and then a fall over the next 120 min to a new steady state was observed. The RCV fell about 5 percent immediately after infusion and then returned in about 20 min to slightly lower than control. The PV transient indicates an initial rapid absorption of water from the interstitial space due to an increase in plasma osmolality; then a balance of forces at the peak PV, possibly through increased capillary hydrostatic pressure, decreased tissue pressure, and decreased capillary osmotic pressure due to dilution of plasma proteins. This was followed by a gradual filtration of water out of the vascular system. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1971
- Accession Number
- AD0732635
Entities
People
- M. B. Wolf
Organizations
- RAND Corporation