Stimulating Action of the L-Glutamine on the Replication of the Venezuelan Equine Encephalomyelitis Virus,

Abstract

Aminoacids have direct significance not only in the process of biosynthesis of protein, but also for the biosynthesis of purine and pirimidine bases. The stimulating influence of glutamine (GLNH2) on the replication of the poliovirus indirectly confirmed its large role in the biosynthesis of virus biomacromolecules. An undoubted stimulating action of GLNH2 on the replication of the virus of Venezuelan equine encephalomyelitis was discovered. The most clear-cut action of the amide appeared during the use, as a medium of support, of the salt solution of Henkes. For replication of the VEE virus, and possibly, other arboviruses, the presence of exogenous GLNH2 is necessary, since the metabolic potentials of cells in relation to biosynthesis of GLNH2 is insufficient to insure the process of virus replication at its optimal rate. Therefore the use of structural analogues of GLNH2 and its antimetabolites in a plan of chemotherapeutic research might be of particular interest.

Document Details

Document Type
Technical Report
Publication Date
Nov 18, 1971
Accession Number
AD0732707

Entities

People

  • A. I. Lvova
  • E. E. Melnikova
  • G. A. Galegov
  • S. Ya. Gaidamovich

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Anabolism
  • Analogs
  • Antimetabolites
  • Arbovirus Infections
  • Arboviruses
  • Arthropod Borne Diseases
  • Bacterial Infections And Mycoses
  • Diseases And Disorders
  • Glutamine
  • Infectious Diseases
  • Mosquito Borne Diseases
  • Rna Virus Infections
  • Venezuelan Equine Encephalomyelitis
  • Venezuelan Equine Encephalomyelitis Virus
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design
  • Virology (or Medical Virology).