Studies of the Preparation, Properties and Physicochemical Characterization of Hydroxyethyl Starch for Use as a Volume-Extender for Blood Plasma.
Abstract
The research described is devoted to a study of the physical chemistry and biochemistry of hydroxyethyl starch, and the manner in which these factors are influenced by the molecular architecture of the derivatized polysaccharide. Part of the report contains a detailed literature review of hydroxyethyl starch and the analytical techniques employed for its examination. The authors have differentiated between two terms which are often used interchangeably when describing the hydroxyethyl derivative namely molar substitution (the number of moles of ethylene oxide which react per mole of monomer unit) and degree of substitution (the mole fraction of anhydroglucose units which carry substituent groups). They have developed a technique whereby the content of unsubstituted glucose residues may be rapidly obtained, and thus the determination of the degree of substitution is, for the first time, a relatively simple procedure. The in vitro degradation of the hydroxyethyl derivative by alpha-amylase was also studied. On the basis of these studies, a mathematical model was constructed for the substitution pattern in hydroxyethyl starch which successfully predicts the seeming anomaly of materials of molar substitution greater than unity being hydrolysed by alpha-amylase.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1971
- Accession Number
- AD0732785
Entities
People
- C. T. Greenwood
Organizations
- University of Edinburgh