Synthesis of Infectious Ribonucleoprotein of Arbovirus in Subcellular Structures,
Abstract
Mitochondrial-microsomal fraction isolated from chick fibroblasts infected with Venezuelan equine encephalomyelitis virus (VEE) and incubated in medium 199 insures extracellular synthesis of virus-specific RNA and proteins and formation of ribonuceloprotein complexes. These complexes possess infectivity which increases 80 to 100 times in 3-4 hours of incubation. The ribonucleoprotein complexes contain infectious RNA, which may be associated both with virus-specific and cellular proteins. The main part of the infectious RNA is formed extracellularly and not at the expense of the completion of templates derived from the cells along with the mitochondrial-microsomal fraction. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 03, 1971
- Accession Number
- AD0733261
Entities
People
- F. I. Ershov
- L. V. Uryvaev.
- V. M. Zhdanov