Biochemistry of Submarine and Diving Stress. 4. Responses of Blood Lactate-Pyruvate and Redox State to Chronic Exposure to 3% CO sub 2
Abstract
Lactate and pyruvate concentrations were measured in blood of guinea pigs exposed to 3% CO2 in 21% O2, balance N2 for varying periods of time up to a week. The redox state, NAD+/NADH ratio was calculated from the lactate/pyruvate ratio and H(+) concentration for each time point. Blood lactate-pyruvate concentrations as well as redox states, were virtually unaffected. It would appear that a respiratory acidosis, induced by exposure to 3% CO2 with a maximum pH decrease of .12 units, is in itself not sufficient to alter glycolytic metabolism of blood in guinea pigs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1971
- Accession Number
- AD0734122
Entities
People
- Arthur A. Messier
- Karl E. Schaefer
- Michael J. Jacey
Organizations
- Naval Submarine Medical Research Laboratory