Synthesis of Organic Compounds for Malaria Chemotherapeutic Studies.
Abstract
The work reported herein consists of an investigation of a structure-activity relationship study on side chain modification of substituted phenanthrene aminoalcohols. During the present report period, a total of 29 compounds have been synthesized, characterized, and submitted for antimalarial evaluation. A number of these have shown curative activity against Plasmodium berghei and P. gallinaceum. Among these compounds, 3,6-bis(trifluoromethyl)-alpha (1-propylbutylaminomethyl)-9-phenanthrenemethanol hydrochloride (WR-167619; AX-29812) was found to possess a 17.7 day activity at 10 mg/kg and is curative at 20 mg/kg against P. berghei. Activity of 3,6-bis(trifluoromethyl)-alpha-(butylaminomethyl)-9-phenanthrenemethanol hydrochloride (WR-165543; AX-27845) is comparable. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1971
- Accession Number
- AD0734362
Entities
People
- C. C. Cheng
- D. J. Mccaustland
- Ping-lu Chien
- William H. Burton
Organizations
- MRIGlobal