Effect of Endotoxin on the S-A Node in situ in the Dog Heart
Abstract
Concentrations of endotoxin equivalent to those producing shock when given intravenously did not affect the S-A pacemaker activity of the dog in situ. Larger amounts of endotoxin, 100 micrograms to 1 mg, directly induced a negative chronotropic response, which was not blocked by atropine treatment. Endotoxin did not influence the effect of vagal stimulation and responses to acetylcholine and norepinephrine injected into the sinus node artery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 30, 1971
- Accession Number
- AD0734655
Entities
People
- Shigetoshi Chiba
- Tamio Nakajima
Organizations
- University of Oklahoma