Per Capita, Per Kilo, Per Liter, or Per Meter: An Analysis of Dose Expressions in Clinical Pharmacology.
Abstract
An attempt was made to define the conditions under which the method of expressing dose might have a significant effect upon the ability to account for the observed variance in pharmacological experiments. A hypothetical model was constructed in which three parameters (dose range, range of response intensity, and experimental error) were assigned reasonably low and high values and the eight possible combinations of these values were used along with other constant or randomly varied factors to generate eight sets of 36 dose-response pairs. From an analysis of these results, it was found that the method of expressing dose made little difference except in the unusual situation wherein variance from other sources was minimal. A similar analysis applied to four actual clinical drug studies yielded results which were in good agreement with the hypothetical model and, in particular, confirmed the original impression that in most drug studies the method of expressing dose is of minor importance if an adequate dose range is used. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1971
- Accession Number
- AD0734830
Entities
People
- Frederick R. Sidell
- James S. Ketchum