The Mechanism of Genetic Recombination in Bacteria and Phages (Mekhanizm Geneticheskoi Rekombinatsii u Balsterii i Fagou),
Abstract
The article discusses the processes of genetic recombination in bacteria and phages. It is shown that in the transformation of bacteria only one of the two complimentary strands enters the chromosome of the recipient cell, and two stranded fragments of DNA are encountered in conjugation. In the transformation, molecular heterozygotes are formed, which are guided by special repair enzymes. Two strand recombinations are also accompanied by the formation of molecular heterozygotes along the ends of the broken fragment. Their correction is the basis of genetic conversion. The insertion of the phage chromosome into the chromosome of the bacterium in the case of lysogeny takes place through cyclization and crossing over (Campbell mechanism). It was shown that the same mechanism of integration and combination of DNA fragments operates in the conjugation of a cell. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1971
- Accession Number
- AD0736143
Entities
People
- S. E. Bresler
Organizations
- United States Army Foreign Science and Technology Center