Thermoinactivation of Viruses. Announcement 2. On the Nature of Abnormalities in the Dynamics of Viral Inactivation
Abstract
The mechanism was studied of the origin of dynamic inactivation irregularities of the viruses of the Venezuelan Equine Encephalitis (VEE), which are formed at 50-55 degrees in the first weeks and months after reproduction. The heterogeneity of the viral population is based on the described phenomenon. The t sup r variant of VEE, isolated from the initial population, was characterized by significant delta N(pr)=95.4 kilocalorie/mole, deltaS(pr)=219.4 E.E. and deltaN(nk)=26.02 kc/mole, deltaS(nk)=8.15 E.E. At 52-56 degrees, the t sup r variant of VEE was inactivated in contrast to the initial strain by the 'nuclein' type that also caused an inactivation dynamics disturbance. The disappearance of the phenomenon after viral incubation at 4 degrees was related to a lowered stability in these conditions of the t sup r viral variant and to its gradual disappearance from the viral population.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1970
- Accession Number
- AD0736274
Entities
People
- A. S. Novokhatskii
- F. I. Ershov