Design and Synthesis of Hemicholiniums and Quarternary Ammonium Compounds with Relatively Great Differences Between the Effective and Lethal Doses
Abstract
Nine selected series of quaternary ammonium compounds were synthesized to study relationships between their chemical structures and their biological activities. A general structure is presented indicating certain common chemical features required to obtain potent hemicholiniums, lethal pyridinium compounds, and other pyridinium compounds with relatively great differences between the effective and lethal doses. A new hemicholinium compound more potent than the original hemicholinium (HC-3) was obtained. General chemical characteristics regarding the compositions of the presynaptic active sites participating in cholinergic neuromuscular impulse transmission are postulated. Possible mechanisms of action of ortho- and meta-pyridinium compounds meeting specific structural requirements are proposed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1971
- Accession Number
- AD0736330
Entities
People
- Harold Z. Sommer
- Omer O. Owens