Continued Studies on the Ontogeny of Mechanisms Controlling Protein Synthesis.
Abstract
The ultimate objective of this work has been to understand mechanisms that control the differentiation of cells derived from the embryonic neural plate. The principal products of this embryonic tissue are neurons, pigment cells, adrenal medullary cells and a variety of connective tissue cells. Since each of these cell types may be distinguished unambiguously by its special use of the amino acid tyrosine, we are, as a first step, trying to determine mechanisms that control tyrosine metabolism as a function of developmental stage. At the moment, special attention is being given to an enzyme that catalyzes the oxidations of tyrosine and dopa and dopamine. Experiments are being done to determine (1) control mechanisms in rates of synthesis and degradation of the enzyme and (2) conditions that dictate its substrate specificity. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 08, 1972
- Accession Number
- AD0736715
Entities
People
- Edward L. Triplett
Organizations
- University of California, Santa Barbara