Hemoglobin Ta-Li: beta83 Gly yields Cys

Abstract

Hemoglobin Ta-Li was discovered in 1970 in one male Chinese subject during our continuing survey for hemoglobin variants among Chinese school children. The subject was born in Ta-Li, Taiwan and was of Taiwanese (Fukienese) ancestry. The brother and mother of the subject also were found to have the Hb Ta-Li; all three are heterozygotes. Chemical structure studies have now established that the structural variation in Hb Ta-Li is located in the Beta chain at Position Beta-83 where a cysteinyl residue replaces the glycine group normally present at that location. In the propositus the relative amounts of Hb Ta-Li and Hb Ao, as determined by column chromatographic separations, were 40:60, respectively.

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Document Details

Document Type
Technical Report
Publication Date
Apr 22, 1971
Accession Number
AD0737147

Entities

People

  • C. -l. Wang
  • C. -s. Liu
  • R. Quentin Blackwell

Organizations

  • Bureau of Medicine and Surgery

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Aspartic Acid
  • Biochemistry
  • Biomedical Research
  • Blood
  • Cell Count
  • Chemistry
  • Chromatography
  • Chronic Diseases
  • Gel Electrophoresis
  • Health Services
  • Hemoglobin
  • Materials
  • Molecules
  • Navy
  • Public Health
  • Thin Layer Chromatography

Readers

  • Gender and Food Studies
  • Molecular and Cellular Biochemistry
  • Wave Propagation and Nonlinear Chaotic Dynamics.