The Effectiveness of Benactyzine Hydrochloride and Other Antimotion Sickness Drugs in New Combinations,

Abstract

Five different drug preparations are compared for their effectiveness in preventing motion sickness with the effectiveness found for the combination of scopolamine 0.6 mg with d-amphetamine 10 mg in previous studies. Promethazine 25 mg plus d-amphetamine 10 mg was essentially equal to the baseline drug in range of effectiveness. Halving the doses of the baseline combination did not provide the protection that it did in an earlier study. Benactyzine 3 mg was only slightly effective and when combined with d-amphetamine 10 mg was only moderately so. Promethazine 25 mg plus ephedrine 25 mg was about one-fourth less effective than the baseline preparation. The unexpected finding of the efficacy of small doses (25 mg) of promethazine plus ephedrine is pointed out, and the benefits from the relatively great reduction in side effects found with this drug combination are stressed. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 06, 1971
Accession Number
AD0737220

Entities

People

  • Ashton Graybiel
  • Charles D. Wood

Organizations

  • Naval Aerospace Medical Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Base Lines
  • Biomedical Research
  • Classification
  • Combinatorial Analysis
  • Drug Combinations
  • Ear
  • Motion Sickness
  • Rotation
  • Security
  • Side Effects
  • Standards
  • Tape Recording

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Toxicology/Environmental Toxicology