The Treatment of Acute Respiratory Failure in Experimental Fat Embolism.
Abstract
Respiratory failure associated with experimental fat embolism was investigated using two experimental models and various therapeutic modalities. The canine oleic acid model of fat embolism was used primarily. In initial experiments it was determined that continuous positive pressure breathingg was more effective than intermittent positive pressure breathin in the treatment of respiratory failure caused by the injection of oleic acid. Corticosteroids seemed to have no particular beneficial effect in this model. This model was also investigated using in vivo observations via a thoracic window to determine alterations in pulmonary microanatomy after fat embolism. Two basic patterns were observed: one of complete vascular occlusion to an area of lung, and a second, of acute toxic vasculities with interstitial hemorrhage, edema, and loss of alveolar stability. Further experiments demonstrated a consumption coagulopathy in the canine oleic acid model and also demonstrated that fibrin was deposited in the pulmonary interstitium and arterioles following fat embolism. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 22, 1972
- Accession Number
- AD0737749
Entities
People
- David G. Ashbaugh
Organizations
- University of Colorado Denver