Investigation of Human Cerebral and Peripheral Glucose and Free Amino Acid Metabolism.
Abstract
Strong evidence is presented that insulin affects the brain, altering the kinetics governing its uptake of glucose and some amino acids. After an overnight fast, the peripheral tissues -- mainly muscle -- of normal males were catabolising protein and releasing amino acids into the circulation: the uptake of glucose was small white that of NEFAs was more clearcut, suggesting that these latter substrates were being used for energy metabolism. Intravenous insulin (approximately 0.1 micron/kg lean body mass) had a marked effect on the peripheral muscles. The tissue glucose threshold fell and glucose uptake by the cells tended to increase. Intravenous insulin also affected the brain uptake of glucose by lowering the threshold in this tissue in a way similar to, but slower than, the peripheral muscles. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1971
- Accession Number
- AD0737819
Entities
People
- J. J. Collins
- M. J. Whichelow
- W. J. H. Butterfield