Synthesis of Spirocyclic Derivatives Related to the Butyrophenone Neuroleptics

Abstract

A number of analogs related to haloperidol were synthesized and submitted for biological evaluation. In the course of the studies, two novel synthetic procedures were developed: The preparation of ketones by addition of acid chlorides to organocopper compounds; and The two-step preparation of secondary amines from tertiary benzyl amines having a divalent sulfur atom in the molecule.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1972
Accession Number
AD0738116

Entities

People

  • Leon J. Schiff
  • Patrick J. Mudd

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Alkanes
  • Alkenes
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Desiccants
  • Ketones
  • Magnesium Compounds
  • Methanols
  • Molecular Weight
  • New York
  • Organic Chemistry
  • Potassium Iodide
  • Spectra
  • Tranquilizing Agents

Fields of Study

  • Chemistry

Readers

  • Organic Chemistry
  • Toxicology/Environmental Toxicology