Some Effects of CBrF3 Inhalation and Epinephrine Challenge on Certain Myocardial Metabolite Levels.
Abstract
Bromotrifluoromethane (CBrF3) would have considerable potential as a closed environment fire extinguishing agent, except for its membership in that large group of hydrocarbons capable of precipitating irregular heart action when inhaled by persons with elevated levels of blood epinephrine. These experiments were an effort to determine whether myocardial metabolism was impaired in male Wistar rats breathing 79/21 CBrF3/O2 and challenged with 1-epinephrine in what would ordinarily constitute sub-toxic dosages. CNS effects were the major observations in rats exposed to both CBrF3 and epinephrine; all control rats survived without apparent effect. The general picture was consistent with the CBrF3 induction of respiratory depression and hypoxia. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 30, 1971
- Accession Number
- AD0739699
Entities
People
- Richard A. Rhoden
Organizations
- Naval Air Warfare Center Warminster