Marrow Transplantation in Aplastic Anemia: An Animal Model.
Abstract
The results of investigations indicate that cyclophosphamide (CY), anti-thymus sera (ATS) and anti-lymphocyte sera (ALS can be used to provide adequate immunosuppression to the busulfan (BU) treated rat so that AgB incompatible marrow grafts may be accepted. LBNF(1) rats but not Lewis rats can be protected from BU toxicity by AgB compatible F344 marrow grafts. BU, therefore, must exert a very minimal immunosuppressive effect measured only in the F344-LBNF(1) system. Furthermore, this immunosuppressive effect is abolished if F344 cells are injected just prior to BU administration. Presensitization of LBNF(1) but not Lewis rats to F344 grafts can be abolished with CY but not with ATS, ALS or ABS. ALS pretreatment is able to abolish the development of transplantation immunity in the F344-LBNF(1) system if given before the sensitizing dose of cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 20, 1972
- Accession Number
- AD0739720
Entities
People
- George W. Santos
Organizations
- Johns Hopkins University