Bone Atrophy by Inactivity,
Abstract
The development of bone atrophy caused by inactivity was investigated in experiments with Guinea pigs. 300 animals of an inbred strain were fixed by a pelvic plaster for different times. The breaking strength of femora was measured and the reduction of spongy bone determined by uncalcified bone sections. Moreover, bone remodelling, dry mass of bone, and mineral balance were tested in our experiments. Bone atrophy is developing rapidly depending upon time of immobilization, age, and sex. The calcium balance is negative from the first day of immobilization. Osteoporotic changes produced by inactivity are compared with results obtained after space flights. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1971
- Accession Number
- AD0740448
Entities
People
- Joachim H. Eichler
Organizations
- Air Force Research Laboratory