Toxigonin and Pralidoxime: A Kinetic Comparison after Intravenous Administration to Man

Abstract

After intravenous administration to humans, the chloride and methane sulfonate salts of pralidoxime were found to have identical pharmacokinetic characteristics. Toxogonin was found to have a much smaller volume of distribution and a lower renal clearance rate. These findings explain the fivefold difference in plasma concentrations after similar doses of toxogonin and pralidoxime.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1972
Accession Number
AD0740737

Entities

People

  • Andris Kaminskis
  • Frederick R. Sidell
  • William A. Graff Sr.

Tags

DTIC Thesaurus Topics

  • Army Personnel
  • Blood
  • Blood Cells
  • Cell Count
  • Chemical Warfare Agents
  • Chlorides
  • Clearances
  • Drug Abuse
  • Equations
  • Experimental Data
  • Health Services
  • Leukocytes
  • Lysergic Acids
  • Medical Personnel
  • Pharmacology
  • Two Dimensional
  • United States

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Electrochemical Engineering/ Fuel Cell Technologies
  • Neurotoxicology