Cardiac Response to Circulating Factors in Endotoxin Shock
Abstract
Findings from the literature suggest the presence of a deleterious factor in the blood of endotoxin-shocked animals. The purpose of the present study was to explore the possibility that myocardial performance is adversely affected by circulating substances released from distant sites and transmitted to the heart via the blood. Experiments were carried out on adult mongrel dogs administered endotoxin. Blood from these animals was subsequently perfused through an isolated working left ventricle from a donar animal. Results show that after 6-9 hours following injection of endotoxin, cardiac performance is normal in comparison to control experiments. Performance curves elicited by altering mean aortic pressure (afterload) from 75-150 mm Hg revealed no important differences between endotoxin and control groups in stroke work, power, dP/dT, left ventricular end diastolic pressure, O2 uptake and CO2 production, coronary flow and resistance. Performance curves demonstrated normal myocardial function even during terminal stages of shock. Results indicate that if deleterious agents are circulating in the blood from endotoxin-treated animals, they do not depress myocardial function.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 13, 1972
- Accession Number
- AD0740794
Entities
People
- G. A. Guenter
- L. B. Hinshaw
- L. J. Greenfield
- L. T. Archer
- S. E. Owen
Organizations
- University of Oklahoma