Drug Therapy of Acute Pulmonary Insufficiency
Abstract
New drugs for the treatment of acute pulmonary insufficiency were developed. The activities were centered on the search for compounds that will correct an increase in capillary permeability. One naphthoquinone and one flavonoid that prevent pulmonary edema and congestion in mice, rats and dogs were selected as candidates. The pulmonary edema induced by inhalation of 25% carbon dioxide in mice and pulmonary congestion induced by paraquat in rats was prevented by prior treatment with either compound. In dogs with pulmonary edema induced by alloxan or inhalation of a chemical irritant, the results were equivocal. The experiments in dogs are continuing and investigation in monkeys is planned.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1972
- Accession Number
- AD0740811
Entities
People
- Domingo M. Aviado
- Steven A. Friedman
Organizations
- University of Pennsylvania