Renal Gluconeogenesis after NH4CL, NaHC03, Hypoglycemia, or Pregnancy
Abstract
Rates of renal gluconeogenesis were determined in intact normal dogs, and in acidotic, bicarbonate-fed, hypoglycemic, or pregnant dogs. Renal plasma flow, arterial and renal venous glucose, pH, and Pco2 were measured. Renal gluconeogenesis was shown in 56% of periods from controls, 40% from acidotic, 75% from alkalotic, 39% from hypoglycemic, and 57% from pregnant dogs. Rates of renal gluconeogenesis in acidotic dogs were significantly lower than in controls. Bicarbonate-fed dogs had a higher rate than controls, but not significantly so. When compared to acidotic dogs, however, the bicarbonate-fed dogs manifested a significantly greater rate of gluconeogenesis. When clearance periods from control, acidotic, and bicarbonate-fed dogs were segregated according to the production or extraction of glucose rather than pH, it was found that periods showing production did not differ in acid-base features from those showing extraction. Hypoglycemic and pregnant dogs did not differ significantly from controls. It appears that in vivo metabolic acidosis does not significantly stimulate rates of renal gluconeogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 16, 1970
- Accession Number
- AD0740914
Entities
People
- David M. Roxe
Organizations
- Naval Medical Research Center