The Metabolism of Fat and Carbohydrate during Hemorrhagic Shock in the Unanesthetized Subhuman Primate: Changes in Serum Levels of Free Fatty Acids, Total Lipids, Insulin, and Glucose

Abstract

Five adult baboons were subjected to hemorrhagic hypotension for a period of 3-1/2 hours, and another five baboons served as the control animals. The animals were studied in a specially designed chair while fully awake. During the period of hypotension, the cardiac output decreased significantly. Thirty minutes after hemorrhage, the serum insulin had fallen, and the glucose had risen. Despite the development of hypoinsulinemia, no statistically significant acute change in the mean serum free fatty acid (FFA) concentration was demonstratable; however, after 3-1/2 hours the mean FFA level was 382 percent of base line in the hypotensive group and not significantly raised in the control animals. Possible reasons why the early hemorrhagic hypoinsulinemia did not lead to the expected early elevation in the FFA's are discussed.

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Document Details

Document Type
Technical Report
Publication Date
Sep 20, 1971
Accession Number
AD0740926

Entities

People

  • Arnold G. Coran
  • Clifford M. Herman
  • David L. Horwitz
  • Philip E. Cryer

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Cyber

DTIC Thesaurus Topics

  • Base Lines
  • Blood
  • Department Of Veterans Affairs
  • Elevation
  • Fatty Acids
  • Hemorrhage
  • Hemorrhagic Shock
  • Hypotension
  • Insulin
  • Lipids

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology